2837: The Methylene Blue Masterclass: Cutting-Edge Mitochondrial Support with Dr. Scott Sherr
Apr 16, 2026
This is one of the BEST interviews we’ve ever done on supplements and cutting-edge supplement technology… We had Dr. Scott Sherr on the podcast — a board-certified internal medicine physician who practices health optimization medicine and hyperbaric oxygen therapy. This guy KNOWS his stuff and we break down some of the most powerful compounds you can get your hands on to improve cognitive function, athletic performance, and longevity.
Here’s the reality… 94% of US adults are metabolically UNHEALTHY. That means your mitochondria — the powerhouses of your cells — are struggling to produce the energy you need. Dr. Sherr explains exactly why this happens, how it connects to everything from anxiety and depression to fat loss struggles, and what you can actually DO about it. We dive DEEP into methylene blue — the first drug ever registered with the FDA back in 1897 — and why it’s become one of the most powerful tools for supporting mitochondrial function and energy production.
But it doesn’t stop there… We cover the GABAergic system and why most people are walking around GABA deficient (hello anxiety, insomnia, and mood issues), the synergy between methylene blue and red light therapy, how to use these compounds for travel, and a complete sleep optimization stack that could finally get you those 90+ Oura Ring scores. If you’re tired of being tired, stressed about being stressed, or just want to understand how to actually support your body at a cellular level — this episode is a MUST listen.
MAPS PPL — https://mapsppl.com (code: ppl)
SPONSORS
Troscriptions — https://troscriptions.com/mindpump (code: mindpump)
Seed — https://seed.com/mindpump (code: 25mindpump)
00:00 — Intro
5:56 — Dr. Scott Sherr’s background and health optimization medicine framework
10:42 — Strengths and weaknesses of conventional vs alternative medicine
16:34 — Why 94% of US adults are metabolically unhealthy
22:30 — The ‘sympathetic spiral of doom’ and why doing MORE isn’t better
25:48 — Deep dive into methylene blue — history and mechanisms
35:09 — MAO inhibition, serotonin syndrome risk, and dosing protocols
42:43 — Methylene blue and red light therapy synergy
48:55 — GABA system, B3-GABA, and the TroCalm formula explained
59:58 — Complete sleep optimization stack and nighttime routine
67:30 — Cordycepin benefits and immune support protocols
PEOPLE MENTIONED
Dr. Scott Sherr — Guest — board-certified internal medicine physician, health optimization medicine practitioner, co-founder of Troscriptions
Dr. Ted Achacoso — Founder of Troscriptions and the Health Optimization Medicine nonprofit, mentor to Dr. Sherr
Alan Sherr — Dr. Sherr’s father — chiropractor for 45+ years who influenced his alternative medicine philosophy
Francisco Gonzalez Lima — Researcher at University of Texas Austin studying methylene blue for Alzheimer’s, TBI, and stroke
Thomas DeLauer — Mutual friend who uses methylene blue 2-3 times per week on high-stress days
Paul Stamets — Referenced regarding mushroom knowledge and Amanita Muscaria/Santa Claus connection
